Meiotic Spindle Has a Soft Spot
نویسندگان
چکیده
منابع مشابه
Meiotic spindle, spindle checkpoint and embryonic aneuploidy.
In mitosis, a spindle checkpoint plays important roles at the metaphase-anaphase transition to ensure the formation of a bipolar spindle, the completion of connecting chromosomes to microtubules and the alignment of all chromosomes at the spindle equator before initiation of anaphase. Components of the spindle checkpoint were first identified through genetic screens in budding yeast and some ch...
متن کاملMeiotic Spindle Structure
Meiotic chromosome segregation leads to the production of haploid germ cells. During meiosis I (MI) the paired homologous chromosomes are separated. Meiosis II (MII) segregation leads to the separation of paired sister chromatids. In the budding yeast, Saccharomyces cerevisiae, both of these divisions take place in a single nucleus, giving rise to the four spored ascus. We have modeled the micr...
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Katanin is a conserved AAA ATPase with the ability to sever microtubules, but its biological function in animal cells has been obscure. A recent study using electron tomography has found that katanin stimulates the production of microtubules in the meiotic spindles of Caenorhabditis elegans oocytes.
متن کاملOocyte Meiotic Spindle Assembly and Function.
Gametogenesis in animal oocytes reduces the diploid genome content of germline precursors to a haploid state in gametes by discarding ¾ of the duplicated chromosomes through a sequence of two meiotic cell divisions called meiosis I and II. The assembly of the microtubule-based spindle structure that mediates this reduction in genome content remains poorly understood compared to our knowledge of...
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Accurate control of spindle length is a conserved feature of eukaryotic cell division. Lengthening of mitotic spindles contributes to chromosome segregation and cytokinesis during mitosis in animals and fungi. In contrast, spindle shortening may contribute to conservation of egg cytoplasm during female meiosis. Katanin is a microtubule-severing enzyme that is concentrated at mitotic and meiotic...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2019
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2019.04.004